Metformin and Weight Loss: Everything Explained - Weightalogue
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Metformin and Weight Loss: Everything Explained

metformin and weight loss

Metformin and weight loss is the phenomenon where a drug called Metformin is used to lose weight. What most people don’t understand about this drug is whether it actually works or is just a myth and that’s what we’ll be discussing in this piece of article.

Every year at our annual physical checkup we all hear our doctor say to watch our weight, eat right and get regular exercise to prevent developing high cholesterol counts, heart disease and couch potato figures. The older and more overweight we get, the sterner are the warnings about losing weight to prevent developing diabetes. We ask the doctor to tell us what the best weight loss regime is or what an easy weight loss program is. One answer is developing out of the treatment of Type 2 diabetes itself.

Metformin and Weight Loss:

The medication Metformin and weight loss have been conclusively shown to be related. Metformin is the preferred drug of choice prescribed for the treatment of Type 2 diabetes, especially for patients with normal kidney function and those who are overweight or morbidly obese.

It is also the only antidiabetic drug available that prevents the cardiovascular complications that diabetics often face.

Studies have conclusively shown that Metformin prevents these.

It works by decreasing your liver’s production of glucose while increasing the cells’ sensitivity to the insulin which your pancreas is already releasing. Thus your body is better able to metabolize glucose and it does not build up in your blood stream.

Researches about Metformin and Weight Loss:

Obesity is known to predispose people to developing Type 2 diabetes. That makes sense since obesity is by its very nature an insulin-resistant state of being. As your body fat percentage and body mass increases, your resistance to insulin does also.

The American Diabetic Association conducted a study with obese patients with non-insulin-dependent diabetes mellitus (NIDDM, or Type 2 diabetes). The control group received a placebo while the experimental group received two doses daily of Metformin. The results indicated that the calorie intake of the Metformin group decreased in a dos-dependent manner and they lose weight compared to the control group.

A larger British study covering six months found that using Metformin for weight loss was very successful in both insulin sensitive and insulin resistant obese patients. The greatest Metformin weight loss of all, however, was in the patients with the most severe insulin resistance. That is very encouraging news for the morbidly obese.

Metformin, then, improves a person’s glycemic control, reduces insulin resistance and helps treat obesity. Though not specifically approved by the FDA for use in weight loss programs, doctors may prescribe this and other medications “off label” for purposes that have not yet been approved because the FDA does not regulate how doctors practice medicine. Therefore, this medication may be helpful in treating other insulin-resistant problems, like fatty liver disease and pre-diabetes.

It also is used to treat polycystic ovary syndrome, where insulin-resistance is believed to be a factor.

Patients who must take a typical antipsychotic drugs like olanzapine for managing their bi-polar disorder or schizophrenia often experience weight gain as a side effect. Studies show that if they also take Metformin they lose that weight or do not gain it if taken with their psychiatric medications. This has very important quality of life implications for these patients.

Does Metformin Cause Weight Loss?

The final question is “Does Metformin cause weight loss?” The most simple answer to summarize with is “yes”. Under certain conditions with certain groups of patients, this medication can be very helpful in fighting obesity and weight gain caused by insulin sensitivity and resistance.

This was all there is about Metformin and weight loss and we recommend you to consult with your doctor before using Metformin for weight loss.